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The detection of HHV-6 in the peripheral blood of patients is considered a possible marker of this condition and has been included in the Japanese (31, 32), but not in the European (19, 33), diagnostic criteria, as further discussed in the related chapter
In addition, the presence of polymorphisms in genes encoding drug-metabolizing enzymes (e.g., cytochrome P 450) may result in the accumulation of the drug or its active metabolites and have been implicated as a cofactor in the development of phenytoin-induced severe adverse cutaneous drug reactions (36)
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